Medical license, Board of Medicine, State of Michigan.
1994-present
Diplomate, The American Board of Pediatrics.
CLINICAL EXPERIENCE AND ACTIVITIES
7/1976-6/1977
Post Graduate studies in biological sciences, Faculty of Medicine, Alexandria, Egypt.
7/1977-6/1978
Internship, University of Alexandria Hospitals, Alexandria, Egypt.
7/1978-6/1980
General medical practice, Alexandria, Egypt.
7/1980-7/1981
Pre-Fellowship, post graduate studies in biological sciences, Medical Institute of Health, Alexandria, Egypt.
8/1982-6/1984
Medical Genetics, diagnosis and counseling, Department of Human Genetics, University of Michigan.
1/1984-6/1984
Sickle Cell Clinic and community screening and counseling, University of Michigan.
3/1985-6/1986
Medical Genetics, diagnosis and counseling, Department of Pediatrics and Human Development, Michigan State University.
7/1987-6/1990
Pediatric Internship and Residency, Department of Pediatrics and Human Development Michigan State University.
4/1988-6/1988
Medical Genetics, diagnosis and counseling, Department of Human Genetics, Yale Medical School, Yale University.
7/1990-12/1990
Medical Genetics, diagnosis and counseling, Johns Hopkins University.
1/1991-9/1993
Medical Director, Children’s Health Center, Battle Creek, MI.
10/1993-9/1994
Pediatric private practice, Ann Arbor, MI.
10/1994- 9/2005
Associate Professor of Pediatrics, Department of Pediatrics and Infectious Diseases, University of Michigan.
10/2005 – present
Excecutive Medical Director and CEO, Dr. Mo Pediatric Center and The Mind & Spirit Institute, Brighton, MI
SCIENTIFIC ACTIVITIES
1981-1982
Research in Cell Biology, Department of Biological Sciences,Bowling Green State University: cytogenetics, mutagenesis and immunology.
1982-1984
Graduate studies, Department of Human Genetics, University of Michigan: cytogenetics, somatic cell genetics and recombinant DNA techniques.
1984-1988
Research and graduate studies in genetics, oncology, mutagenesis and intercellular communication. Department of Pediatrics and Human Development, Michigan State University.
1988
Collaborative research on oncogene expression and intercellular communication Department of Pathology, Yale University.
1991
Postdoctoral research in cell and molecular biology, regulation of gene expression utilizing reporter genes. Department of Biochemistry, Michigan State University.
HONORS AND AWARDS
1986
Recipient of the Annual Wilton R. Earle Research Award, the Tissue Culture Association, U.S.A.
1986
Recipient of the Annual Research Award from the Center of Environmental Toxicology, Michigan State University.
1986-1987
Graduate Assistantship, Department of Pediatrics and Human Development, Michigan State University.
PROFESSIONAL MEMBERSHIPS
1990-present
Fellow, American Academy of Pediatrics
1985-present
American Society of Human Genetics
1992-present
Mission Health Staff membership
TEACHING ACTIVITIES/PRESENTATIONS
1987
Teaching Assistant, College of Natural Sciences, Genetics Course, Michigan State University.
1987-1990
Lecturer, Department of Pediatrics and Human Development, Michigan State University.
1994- 2005
Assistant Professor of Pediatrics, Department of Pediatrics and Infectious Diseases, University of Michigan, Ann Arbor, MI. Teaching medical students and residents.
December 1986
Collaborative research and seminar presentation on Oncogenes and Intercellular Communication. Massachusetts Institute of Technology, The Whitehead Institute hosted by Drs. Paolo Dotto and Robert Weinberg.
March, 1987
Collaborative research and seminar presentation at the Department of Pathology, Yale School of Medicine, Yale University. Host: Paolo Dotto, M.D., Ph.D.
April, 1987
Invited speaker at the Department of Biological Sciences Bowling Green State University, Bowling Green, Ohio. Host: William Baxter, Ph.D.
May 1987
Keynote address at the Tenth Cancer Update Symposium American Cancer Society, Michigan Chapter, Marquette, Michigan.
November, 1988
Genetics Grand Rounds: Acid Lipase Deficiency: Wolman’s Disease and Cholesterylester Storage Disease. Department of Human Genetics, Yale School of Medicine, Yale University. Host: Dr. M. Seashore.
February, 1989
Pediatric Grand Rounds: Oncogenes and the Genetic Etiology of Cancer. Department of Pediatrics and Human Development, Michigan State University.
March, 1989
General Pediatric Rounds: Clinical Approach to Metabolic Acidosis. Department of Pediatrics and Human Development, Michigan State University.
August, 1989
General Pediatric Rounds: Advances in Molecular Genetics. Department of Pediatrics and Human Development, Michigan State University.
November, 1989
Keynote address at the annual meeting of the Cystic Fibrosis Program Directors in Michigan: Cloning of the CF gene, implications for diagnosis, counseling and treatment. Michigan State University, Host: Dr. Richard Honicky.
December, 1991
Teaching Rounds: Malignant Transformation and Tumor Suppression. Departments of Internal Medicine and Hematology/Oncology, Hurley Medical Center, Flint, Michigan.
April, 1992
Guest Speaker at the 10th meeting of the Professionals in Advanced Pediatrics of West Michigan: Pediatric Genetics for the Clinician.
May, 1992
Guest Speaker at the Annual Pediatric Symposium, Kalamazoo Center for Medical Sciences: Clinical Genetics for the Practitioner.
January, 1993
Organized and presented workshop on Asthma for the Battle Creek Community.
December, 1993
Pediatrics Grand Rounds, Saint Joseph Mercy Hospital, Ann Arbor, MI: Common Genetic disorders in pediatric practice.
February, 1994
Grand Rounds presentation, Department of Obstetrics and Gynecology, Saint Joseph Mercy Hospital, Ann Arbor, MI: Cystic Fibrosis, overview and current advances in therapy.
1994-2005
Teaching and supervision of pediatric interns, residents and medical students in hospital and office.
1995-2005
Recurring Pediatric Seminar Series for expecting parents: University of Michigan Medical Center, Brighton, MI.
COMMITTEE MEMBERSHIPS AND ADMINISTRATIVE SERVICES
1/1992-9/1993
Medical Director, Children Health Center, Battle Creek, MI.
1/1992-9/1993
Member, Board of Directors, Children Health Center, Battle Creek,.MI.
6/1998-12/2000
Elected Chair, Pediatric Primary Care Council, Department of Pediatrics, University of Michigan.
6/1998-5/2001
Member, Pediatric Primary Care Council, Department of Pediatrics, University of Michigan.
1/1998-9/2005
Director of Medical Student Education in pediatrics at Brighton H.C.
6/1999-5/2000
Member, Pediatric Faculty Search Committee, University of Michigan.
3/2005-Present
Member, Board of Directors, The Community Coordiated Child Care (4Cs), Livingston County, MI.
BIBLIOGRAPHY
Peer Reviewed Publications
Chang, CC, Trosko, JE, El-Fouly, MH, Gibson-D’Ambrosio, R and D’Ambrosio, SM: Contact insensitivity of a subpopulation of normal human fetal kidney epithelial cells and of human carcinoma cell lines. Cancer Res. 47, 1634-1645,1987.
El-Fouly, MH, Trosko, JE and Chang, CC: Scrape-loading and dye transfer: a rapid and simple technique to study gap-junctional intercellular communication. Exp. Cell Res. 168: 422-430, 1987.
Kavanagh, TJ, Martin, GM, El-Fouly, MH, Trosko, JE, Chang, CC and Rabinovitch, PS: Flow cytometry and Scrape-loading/dye transfer as a rapid quantitative measure of intercellular communication in vitro. Cancer Res. 47: 6046-6051,1987.
Suter, S, Trosko, JE, Chang, CC, El-Fouly, MH, Koestner, A and Lockwood, E: Dieldrin inhibition of gap junctional intercellular communication in rat glial cells as measured by the fluorescence photobleaching and scrape-loading/dye transfer assays. Fund. Appl. Toxicol. 9: 785-794, 1987.
Evans, MG, El-Fouly, MH, Trosko, JE and Sleight, S, Anchored cell analysis/ sorting coupled with the scrape-loading/dye transfer technique to quantify inhibition of gap-junctional intercellular communication in WB-F344 cells by 2,2′,4,4′,5,5′-hexabromobiphenyl. J. Toxicol. Environ. Health, 24: 261-271,1988.
Dotto, GP, El-Fouly, MH, Nelson, C and Trosko, JE: Similar and synergistic inhibition of gap-junctional communication by ras transformation and tumor promoter treatment of mouse keratinocytes. Oncogene 4: 637-641, 1989.
El-Fouly, MH, Trosko, JE, Chang, CC and Warren, ST: Potential role of the Human Ha-ras oncogene in the inhibition of gap junctional intercellular communication. Mol. Carcinogenesis 2:131-135, 1989.
El-Fouly, MH, Higgins, JV, Kapur, S, Sankey, BJ, Matisoff, DN and Costa-Fox, M: DiGeorge anomaly in an infant with deletion of chromosome 22 and Dup (9p) due to adjacent type II disjunction. Am. J. Med. Gen.38:569-573, 1991.
El-Fouly, M.H., J.M.M.J.G. Aarts, A. Brouwer, and M.S. Denison,”Production of Novem Recombinant Cell Line Bioassay Systems for Detection of 2,3,7,8-Tetrachlorodibenzo-p-dioxin-like Chemicals”, Proceedings of the International Dioxin Conference, Vienna, Austria, 1993.
El-Fouly, MH, Richter, C, Giesy, JP, Denison, MS: Production of a novel recombinant cell line for use as a bioassay system for the detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals. Environmental Toxicology and Chemistry, vol. 13, 1581-1588, 1994 .
Dissertations And Review Articles
El-Fouly, MH: Cytogenetic effects and sister chromatid exchange induction by 2,4-dichlorophenoxyacetic acid (2,4-D) in Chinese hamster cells (V79). Thesis for Master of Science. Bowling Green State University, Bowling Green, Ohio, 1982.
Swinford, AE and El-Fouly, MH: Islamic religion and culture: Principles and implications for Genetic counseling. Birth Defects Original Articles Series 23: 253-257, 1987.
El-Fouly, MH: Effects of H-ras oncogene expression on gap junction-mediated intercellular communication in mammalian cells. Doctoral dissertation, Michigan State University, East Lansing, Michigan, l988.
Trosko, JE, Chang, CC, Madhukar, BV, Oh, SY, Bombick, D and El-Fouly, MH, Modulation of gap junctional intercellular communication by tumor promoting chemicals, oncogenes and growth factors during carcinogenesis. In: Gap junctions, Proceedings of the International Conference on Gap Junctions, July, 1987 (Hertzberg, EL and Johnson, RG, eds.) Alan R. Liss, Inc., New York, pp. 435-448, 1988.
MANUSCRIPTS, ABSTRACTS AND RESEARCH PRESENTATIONS
Bombick, D, Chang, CC, El-Fouly, MH, Trosko, JE and Matsumura, F: Inhibition of gap-junctional communication in NIH 3T3 cells with elevated levels of protein kinase C and pp60 src. Poster presentation at the 4th Decennial Review, Cell and Tissue Culture International Conference, Hershey, PA,1986.
Draznin, MB, El-Fouly, MH, Erickson, LM and Trosko, JE: Drugs and factors which promote growth of aorta smooth muscle cells in vitro block cell-cell communication: application of a rapid in vitro assay. Poster presentation, American Federation of Clinical Research,1986a.
Draznin, MB, El-Fouly, MH, Erickson, LM and Trosko, JE: Insulin blocks cell-cell communication in cultured bovine aorta smooth muscle cells: application of a rapid in vitro assay to study hormonal acceleration of atherogenesis. Poster presentation at the annual meeting of the American Diabetes Association, 1986b.
Evans, MG, El-Fouly, MH and Trosko, JE: Application of the scrape-loading/dye transfer assay to determine dose/response of 2,2′,4,4′,5,5′-hexa-bromobiphenyl on inhibition of gap junctional intercellular communication in vitro. Presented at the 37th annual meeting of Veterinary Pathologist. New Orleans, LA, 1986a.
Evans, MG, El-Fouly, MH and Trosko, JE: Fluorescence quantitation of the scrape-loading/dye transfer assay to measure inhibited cell-cell communication in WB cells by PBB and Dieldrin. Poster presentation at the annual meeting of the Society of Toxicology, Washington, D.C.,1986b.
Gera, R, Kulkarni, R, El-Fouly, MH, Chang, CC and Trosko, JE: Inhibition of intercellular communication in human carcinoma cells of various origins as determined by three newly developed methods. Presented at the 78th annual meeting of the American Association of Cancer Research, Atlanta, GA, 1986.
Trosko, JE, Chang, CC, El-Fouly, MH, Kulkarni, R and Gera, R: Role of gap junctional intercellular communication in the regulation of growth and differentiation of normal and malignant human epithelial cells. Poster presentation at the 4th Decennial Review, Cell and Tissue Culture International Conference, the Tissue Culture Association, Hershey, PA, 1986.
Madhukar, BV, Trosko, JE, Chang, CC and El-Fouly, MH: Inhibition of gap junctional communication in normal human keratinocytes by various growth factors and tumor promoters. Poster presentation at the 38th annual meeting of the Tissue Culture Association, Washington, D.C.,1987.
Trosko, JE, Chang, CC, Madhukar, BV, Oh, SY, Bombick, DW and El-Fouly, MH: Use of FRAP analysis, scrape-loading/dye transfer and cell mat assays to study gap junctional communication. Poster presentation at the International Conference on Gap Junctions, Pacific Grove, CA, 1987.
Trosko, JE, Madhukar, BV, El-Fouly, MH and Chang, CC: Evidence for different mechanisms in modulating gap junctional communication by TPA and organochlorine in hamster V79 and rat liver cells. Poster presentation at the 38th annual meeting of the Tissue Culture Association, Washington, D.C.,1987.
El-Fouly, MH, Trosko, JE and Chang, CC: Phenotypic transformation and inhibition of gap junctional communication in epithelial and mesenchymal cells by the Neu oncogene. Poster presentation at the fourth annual meeting on Oncogenes. Hood College, Frederick, MD,1988.
El-Fouly, MH, Trosko, JE, Nelson, C and Dotto, GP: Effects of Ca++, TPA and H-ras oncogene on gap junctional intercellular communication in primary epithelial cells. Poster presentation at the 39th annual meeting of the Tissue Culture Association, Las Vegas, Nevada,1988.
Lilly, SG, deFeyter, E, Weghorst, CM, Chang, CC , Madhukar, BV, El-Fouly, MH, Trosko, JE and Klaunig, JE: Reduced gap junctional intercellular communication and tumorigenicity of rat liver epithelial (“oval”, F344-WB) cells. The Toxicologist 9(1): A490, 1989.
Trosko, JE, Klaunig, JE, Yaeger, M, Koestner, A, El-Fouly, MH, Buboltz, J, Cool, B and Chang, CC: Correlation between the reduction of gap junctional communication and tumorigenesis in rat glial and liver epithelial cells containing the expressed neu oncogene. Abstract for poster presentation, submitted to The Society of Toxicology, 1990 Annual Meeting, l989.
El-Fouly, MH, Portman, M and Sciamanna, D: Combined facio-auriculo-vertebral spectrum and situs inversus totalis in a viable newborn. Published abstract in Am. J. Hum. Gen., October 1990.
El-Fouly, MH and Denison, MS: A new bioassay utilizing an inducible recombinant reporter gene for the detection of a family of receptor-mediated teratogens. Poster presentation, Proceedings of the 8th International Congress of Human Genetics, Washington, D.C. Am. J. Hum. Gen. 49 (4) A 1291, 1991.
El-Fouly, MH, Higgins, JV, Steigman, CK, Walker, J and Sciamanna, DS: VATER association with central nervous system malformations. Poster presentation, Proceedings of the 8th International Congress of Human Genetics, Washington, D.C. Am. J. Hum. Gen. 49 (4) A 868, 1991.
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